| First Author | Nagatake T | Year | 2019 |
| Journal | Mucosal Immunol | Volume | 12 |
| Issue | 5 | Pages | 1082-1091 |
| PubMed ID | 31142830 | Mgi Jnum | J:294490 |
| Mgi Id | MGI:6456458 | Doi | 10.1038/s41385-019-0175-z |
| Citation | Nagatake T, et al. (2019) BLT1 mediates commensal bacteria-dependent innate immune signals to enhance antigen-specific intestinal IgA responses. Mucosal Immunol 12(5):1082-1091 |
| abstractText | Leukotriene B4 receptor 1 (BLT1) triggers the migration of granulocytes and activated T cells; however, its role in B-cell function remains unclear. Here we report that BLT1 is required to induce the production of antigen-specific IgA against oral vaccine through mediating innate immune signals from commensal bacteria. B cells acquire BLT1 expression during their differentiation to IgA(+) B cells and plasma cells in Peyer's patches and the small intestinal lamina propria, respectively. BLT1 KO mice exhibited impaired production of antigen-specific fecal IgA to oral vaccine despite normal IgG responses to systemically immunized antigen. Expression of MyD88 was decreased in BLT1 KO gut B cells and consequently led to diminished proliferation of commensal bacteria-dependent plasma cells. These results indicate that BLT1 enhances the proliferation of commensal bacteria-dependent IgA(+) plasma cells through the induction of MyD88 and thereby plays a key role in the production of antigen-specific intestinal IgA. |
