| First Author | Garchon HJ | Year | 1991 |
| Journal | Nature | Volume | 353 |
| Issue | 6341 | Pages | 260-2 |
| PubMed ID | 1896073 | Mgi Jnum | J:11442 |
| Mgi Id | MGI:59877 | Doi | 10.1038/353260a0 |
| Citation | Garchon HJ, et al. (1991) Identification and mapping to chromosome 1 of a susceptibility locus for periinsulitis in non-obese diabetic mice. Nature 353(6341):260-2 |
| abstractText | Insulin-dependent diabetes mellitus (IDDM) is a polygenic disease caused by autoimmune destruction of insulin-producing beta cells in the islets of Langerhans. Its onset is preceded by a long and variable period in which lymphoid cells infiltrate the pancreas but first remain outside the islets (peri-insulitis) before invading them (insulitis). Among susceptibility loci, only the major histocompatibility complex (MHC) has been clearly assigned. Genetic study of the nonobese diabetic (NOD) mouse model for insulin-dependent diabetes mellitus has revealed genetic linkage of insulitis and of early onset diabetes with two non-MHC loci mapping to chromosome 3 and 11 respectively. Here we report a close association of periinsulitis with a third non-MHC locus mapping to chromosome 1. Successive stages in the progression of diabetic disease thus appear to be controlled by distinct genes or sets of genes. |
