| First Author | Bizon J | Year | 2007 |
| Journal | Neurobiol Aging | Volume | 28 |
| Issue | 3 | Pages | 440-6 |
| PubMed ID | 16504344 | Mgi Jnum | J:121175 |
| Mgi Id | MGI:3709464 | Doi | 10.1016/j.neurobiolaging.2006.01.004 |
| Citation | Bizon J, et al. (2007) Intact spatial learning in adult Tg2576 mice. Neurobiol Aging 28(3):440-6 |
| abstractText | Tg2576 mice, a transgenic model of amyloid pathology associated with Alzheimer's disease (AD), develop measurable levels of soluble amyloid beta1-40 and 1-42 by 6 months of age and amyloid plaque deposition in cortex, hippocampus and amygdala by 10 months of age. To investigate whether non-hippocampal learning strategies would predominate coincident with the age-related increase in Abeta load in the hippocampal region, we measured learning strategies in the T-maze and a redundant cued version of the water maze. Each of these tasks can be solved using either hippocampal or non-hippocampal learning strategies and has proved sensitive to hippocampal disruption in other settings. The results revealed subtle differences in T-maze and water maze performance in Tg2576 mice compared to controls. Surprisingly, however, Tg2576 mice were not impaired relative to non-transgenic littermates on any measures of hippocampal dependent behavior assessed in these tasks. These data suggest that the medial temporal lobe retains considerable function in 15-month-old Tg2576 mice despite significant Abeta pathology. |
