| First Author | Ikarashi Y | Year | 2004 |
| Journal | Neurobiol Aging | Volume | 25 |
| Issue | 4 | Pages | 483-90 |
| PubMed ID | 15013569 | Mgi Jnum | J:128771 |
| Mgi Id | MGI:3768003 | Doi | 10.1016/S0197-4580(03)00122-2 |
| Citation | Ikarashi Y, et al. (2004) Decreased level of brain acetylcholine and memory disturbance in APPsw mice. Neurobiol Aging 25(4):483-90 |
| abstractText | To clarify whether amyloid beta protein (Abeta) amyloidosis induces a disturbance of cholinergic system leading to long-term memory deficits, we continuously examined memory disturbance using the passive-avoidance task, and measured Abeta burden and concentrations of acetylcholine in the brain of APPsw transgenic mice. Repetitive retention trials of the passive-avoidance task showed that the long-term memory impairment in APPsw mice appeared from approximately 7.75 months old and progressively advanced. Significant decreases in acetylcholine levels were found in the brains of 10-month-old mice. A few senile plaques appeared in the cerebral cortex and the hippocampus at 8 months old, and increased in size and number with aging. The concentrations of brain Abeta40/42(43) gradually increased from 8 months old and exponentially increased thereafter. Advance of long-term memory disturbance was closely correlated with Abeta40/42(43) burden. These findings suggested that Abeta accumulation induced long-term memory impairment and disturbance of the cholinergic system, and that the passive-avoidance task and measuring acetylcholine were useful methods for evaluating this mouse model as well as Abeta accumulation. |
