| First Author | Wang Y | Year | 2022 |
| Journal | Int J Mol Sci | Volume | 23 |
| Issue | 5 | PubMed ID | 35269905 |
| Mgi Jnum | J:337171 | Mgi Id | MGI:7255789 |
| Doi | 10.3390/ijms23052757 | Citation | Wang Y, et al. (2022) Low-Dose Delta-9-Tetrahydrocannabinol as Beneficial Treatment for Aged APP/PS1 Mice. Int J Mol Sci 23(5) |
| abstractText | Studies on the effective and safe therapeutic dosage of delta-9-tetrahydrocannabinol (THC) for the treatment of Alzheimer's disease (AD) have been sparse due to the concern about THC's psychotropic activity. The present study focused on demonstrating the beneficial effect of low-dose THC treatment in preclinical AD models. The effect of THC on amyloid-beta (Abeta) production was examined in N2a/AbetaPPswe cells. An in vivo study was conducted in aged APP/PS1 transgenic mice that received an intraperitoneal injection of THC at 0.02 and 0.2 mg/kg every other day for three months. The in vitro study showed that THC inhibited Abeta aggregation within a safe dose range. Results of the radial arm water maze (RAWM) test demonstrated that treatment with 0.02 and 0.2 mg/kg of THC for three months significantly improved the spatial learning performance of aged APP/PS1 mice in a dose-dependent manner. Results of protein analyses revealed that low-dose THC treatment significantly decreased the expression of Abeta oligomers, phospho-tau and total tau, and increased the expression of Abeta monomers and phospho-GSK-3beta (Ser9) in the THC-treated brain tissues. In conclusion, treatment with THC at 0.2 and 0.02 mg/kg improved the spatial learning of aged APP/PS1 mice, suggesting low-dose THC is a safe and effective treatment for AD. |
