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Allele : Lhx1<tm3Bhr> LIM homeobox protein 1; targeted mutation 3, Richard R Behringer

Primary Identifier  MGI:2385727 Allele Type  Targeted
Attribute String  Inserted expressed sequence, Null/knockout Gene  Lhx1
Transmission  Germline Strain of Origin  129S7/SvEvBrd-Hprt1<+>
Is Recombinase  false Is Wild Type  false
molecularNote  A floxed neo cassette was inserted into intron 1 via homologous recombination. The 5' and 3' arms of homology were modified to contain two missense mutations affecting conserved cysteine residues in both exons 1 and 2, which encode the LIM domains essential for zinc-finger structure.
  • mutations:
  • Disruption caused by insertion of vector
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

4 Publication categories