| First Author | Zanconato F | Year | 2016 |
| Journal | Cancer Cell | Volume | 29 |
| Issue | 6 | Pages | 783-803 |
| PubMed ID | 27300434 | Mgi Jnum | J:232329 |
| Mgi Id | MGI:5776625 | Doi | 10.1016/j.ccell.2016.05.005 |
| Citation | Zanconato F, et al. (2016) YAP/TAZ at the Roots of Cancer. Cancer Cell 29(6):783-803 |
| abstractText | YAP and TAZ are highly related transcriptional regulators pervasively activated in human malignancies. Recent work indicates that, remarkably, YAP/TAZ are essential for cancer initiation or growth of most solid tumors. Their activation induces cancer stem cell attributes, proliferation, chemoresistance, and metastasis. YAP/TAZ are sensors of the structural and mechanical features of the cell microenvironment. A number of cancer-associated extrinsic and intrinsic cues conspire to overrule the YAP-inhibiting microenvironment of normal tissues, including changes in mechanotransduction, inflammation, oncogenic signaling, and regulation of the Hippo pathway. Addiction to YAP/TAZ thus potentially represents a central cancer vulnerability that may be exploited therapeutically. |
