| First Author | Hirunwidchayarat W | Year | 2017 |
| Journal | Biochem Biophys Res Commun | Volume | 490 |
| Issue | 4 | Pages | 1294-1300 |
| PubMed ID | 28687491 | Mgi Jnum | J:254323 |
| Mgi Id | MGI:6103089 | Doi | 10.1016/j.bbrc.2017.07.012 |
| Citation | Hirunwidchayarat W, et al. (2017) Site-specific regulation of oral mucosa-recruiting CD8(+) T cells in a mouse contact allergy model. Biochem Biophys Res Commun 490(4):1294-1300 |
| abstractText | Contact allergy is a T cell-mediated, delayed-type hypersensitivity generated by contact exposure of an allergen to the skin and mucosal surface. The clinical manifestations of allergic responses between the skin and oral mucosa vary and the differences in immunopathology have not been clarified. We generated hapten-induced contact hypersensitivity (CH) of the buccal mucosa (BM) in parallel studies with ear skin (ES) CH, and observed several characteristic findings of BM CH. The BM challenge induced more rapid and more severe inflammation than the ES challenge, with abundant granulocyte and CD8(+) T cell infiltration. However, these inflammatory responses diminished quickly. Recruiting CD8(+) T cells in the BM had higher ratios of CD62L(-)CD44(low-hi) memory-type cells, and showed impaired IFN-gamma, greater PD-1, and comparable Ki-67 expression, suggesting that the recruiting-proliferating CD8(+) T cells were unable to differentiate into effector T cells and converted into exhausted T cells at the local site. This finding may explain the rapid recovery of the BM from severe inflammation. Preferentially greater expression of PD-1 ligand (B7-H1), was observed in the BM epithelium under the peak inflammation, and the absence of B7-H1 further accelerated CH responses, suggesting the occurrence of PD-1:B7-H1-mediated immune regulation at the local site. Our results may facilitate the understanding of the unique features of contact allergies in the oral mucosa, and guide the development of new strategies for control of contact allergy. |
