| First Author | Claus C | Year | 2012 |
| Journal | Cancer Res | Volume | 72 |
| Issue | 14 | Pages | 3664-76 |
| PubMed ID | 22628427 | Mgi Jnum | J:189295 |
| Mgi Id | MGI:5445022 | Doi | 10.1158/0008-5472.CAN-11-2791 |
| Citation | Claus C, et al. (2012) CD27 signaling increases the frequency of regulatory T cells and promotes tumor growth. Cancer Res 72(14):3664-76 |
| abstractText | Signaling of the TNF receptor superfamily member CD27 activates costimulatory pathways to elicit T- and B-cell responses. CD27 signaling is regulated by the expression of its ligand CD70 on subsets of dendritic cells and lymphocytes. Here, we analyzed the role of the CD27-CD70 interaction in the immunologic control of solid tumors in Cd27-deficient mice. In tumor-bearing wild-type mice, the CD27-CD70 interaction increased the frequency of regulatory T cells (Tregs), reduced tumor-specific T-cell responses, increased angiogenesis, and promoted tumor growth. CD27 signaling reduced apoptosis of Tregs in vivo and induced CD4(+) effector T cells (Teffs) to produce interleukin-2, a key survival factor for Tregs. Consequently, the frequency of Tregs and growth of solid tumors were reduced in Cd27-deficient mice or in wild-type mice treated with monoclonal antibody to block CD27 signaling. Our findings, therefore, provide a novel mechanism by which the adaptive immune system enhances tumor growth and may offer an attractive strategy to treat solid tumors. |
