| Primary Identifier | MGI:2386438 | Allele Type | Targeted |
| Attribute String | Null/knockout, Reporter | Gene | Wrn |
| Transmission | Germline | Strain of Origin | Not Specified |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The 3'-most exon encoding part of the catalytic helicase domain was replaced with a beta-geo cassette via homologous recombination. The null allele was confirmed by Western blot analysis of ear fibroblasts derived from homozygous mutant animals. No protein product was detected using antibodies directed against the N- and C-terminal regions of Wrn. |
