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Allele : Blnk<tm1Kplm> B cell linker; targeted mutation 1, Kong-Peng Lam

Primary Identifier	MGI:2386672	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Blnk
Transmission	Germline	Strain of Origin	129P2/OlaHsd
Is Recombinase	false	Is Wild Type	false

molecularNote

The first coding exon and 4.5 kb of upstream sequence were replaced by a neomycin selection cassette. Expression was undetected in homozygous mutant mice by RT-PCR analysis of bone marrow and spleen samples.

mutations:
Insertion,
Intragenic deletion

cellLines:
Not Specified

synonyms:
BLNK<->,
SLP-65<->,
SLP-65<->,
BLNK<->

earliestPublication:
Xu S, et al. (2000) B cell development and activation defects resulting in xid-like immunodeficiency in BLNK/SLP-65-deficient mice. Int Immunol 12(3):397-404

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

8 Publication categories

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