| First Author | Revenco T | Year | 2017 |
| Journal | Stem Cells | Volume | 35 |
| Issue | 5 | Pages | 1355-1364 |
| PubMed ID | 28100039 | Mgi Jnum | J:260064 |
| Mgi Id | MGI:6092948 | Doi | 10.1002/stem.2571 |
| Citation | Revenco T, et al. (2017) Low Dose Radiation Causes Skin Cancer in Mice and Has a Differential Effect on Distinct Epidermal Stem Cells. Stem Cells 35(5):1355-1364 |
| abstractText | The carcinogenic effect of ionizing radiation has been evaluated based on limited populations accidently exposed to high dose radiation. In contrast, insufficient data are available on the effect of low dose radiation (LDR), such as radiation deriving from medical investigations and interventions, as well as occupational exposure that concern a large fraction of western populations. Using mouse skin epidermis as a model, we showed that LDR results in DNA damage in sebaceous gland (SG) and bulge epidermal stem cells (SCs). While the first commit apoptosis upon low dose irradiation, the latter survive. Bulge SC survival coincides with higher HIF-1alpha expression and a metabolic switch upon LDR. Knocking down HIF-1alpha sensitizes bulge SCs to LDR-induced apoptosis, while upregulation of HIF-1alpha in the epidermis, including SG SCs, rescues cell death. Most importantly, we show that LDR results in cancer formation with full penetrance in the radiation-sensitive Patched1 heterozygous mice. Overall, our results demonstrate for the first time that LDR can be a potent carcinogen in individuals predisposed to cancer. Stem Cells 2017;35:1355-1364. |
