| Primary Identifier | MGI:2386703 | Allele Type | Targeted |
| Attribute String | Conditional ready, No functional change | Gene | Pdha1 |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exon 8 was left flanked by loxP sites after a downstream floxed tk-neo cassette was excised by the in vitro expression of cre recombinase. Western blot analysis of homozygous mutant ES cells showed normal levels of both isoforms produced by the endogenous allele. Mice carrying this allele were bred to transgenic mice expressing cre in the germline to generate Pdha1tm1.1Ptl. |
