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Allele : Pdha1<tm1.1Ptl> pyruvate dehydrogenase E1 alpha 1; targeted mutation 1.1, Mulchand S Patel
Primary Identifier  MGI:2386704 Allele Type  Targeted
Attribute String  Null/knockout Gene  Pdha1
Transmission  Germline Strain of Origin  129P2/OlaHsd
Is Recombinase  false Is Wild Type  false
molecularNote  The floxed region of Pdha1tm1Ptl containing exon 8 was excised by the expression of cre recombinase in vivo. Studies of an ES cell line recombined in vitro showed highly reduced levels of endogenous protein as well as a near ablation of pyruvate dehydrogenase activity.
  • mutations:
  • Intragenic deletion,
  • Insertion
  • synonyms:
  • Pdha1<delta ex8>,
  • Pdha1<delta ex8>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

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0 Driven By

5 Publication categories





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