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Allele : Hic1<tm1Sbb> hypermethylated in cancer 1; targeted mutation 1, Stephen B Baylin

Primary Identifier	MGI:2386879	Allele Type	Targeted
Attribute String	Null/knockout, Reporter	Gene	Hic1
Transmission	Germline	Strain of Origin	129S4/SvJae
Is Recombinase	false	Is Wild Type	false

molecularNote

The entire gene coding region was deleted and replaced with a lacZ-PGK-neo cassette via homologous recombination. Northern blot analysis of whole embryo total RNA showed an absence of gene expression in homozygous mutants.

mutations:
Intragenic deletion,
Insertion

cellLines:
Not Specified

synonyms:
Hic1-,
Hic1-

earliestPublication:
Carter MG, et al. (2000) Mice deficient in the candidate tumor suppressor gene Hic1 exhibit developmental defects of structures affected in the Miller-Dieker syndrome. Hum Mol Genet 9(3):413-9

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

12 Publication categories

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