| First Author | Guo Y | Year | 2014 |
| Journal | J Immunol | Volume | 192 |
| Issue | 7 | Pages | 3336-44 |
| PubMed ID | 24610012 | Mgi Jnum | J:210244 |
| Mgi Id | MGI:5569858 | Doi | 10.4049/jimmunol.1301949 |
| Citation | Guo Y, et al. (2014) Dissecting the role of retinoic acid receptor isoforms in the CD8 response to infection. J Immunol 192(7):3336-44 |
| abstractText | Vitamin A deficiency leads to increased susceptibility to a spectrum of infectious diseases. The studies presented dissect the intrinsic role of each of the retinoic acid receptor (RAR) isoforms in the clonal expansion, differentiation, and survival of pathogen-specific CD8 T cells in vivo. The data show that RARalpha is required for the expression of gut-homing receptors on CD8(+) T cells and survival of CD8(+) T cells in vitro. Furthermore, RARalpha is essential for survival of CD8(+) T cells in vivo following Listeria monocytogenes infection. In contrast, RARbeta deletion leads to modest deficiency in Ag-specific CD8(+) T cell expansion during infection. The defective survival of RARalpha-deficient CD8(+) T cells leads to a deficiency in control of L. monocytogenes expansion in the spleen. To our knowledge, these are the first comparative studies of the role of RAR isoforms in CD8(+) T cell immunity. |
