| First Author | Sander M | Year | 2000 |
| Journal | Genes Dev | Volume | 14 |
| Issue | 17 | Pages | 2134-9 |
| PubMed ID | 10970877 | Mgi Jnum | J:64376 |
| Mgi Id | MGI:1889153 | Doi | 10.1101/gad.820400 |
| Citation | Sander M, et al. (2000) Ventral neural patterning by Nkx homeobox genes: Nkx6.1 controls somatic motor neuron and ventral interneuron fates. Genes Dev 14(17):2134-9 |
| abstractText | There is growing evidence that sonic hedgehog (Shh) signaling regulates ventral neuronal fate in the vertebrate central nervous system through Nkx-class homeodomain proteins. We have examined the patterns of neurogenesis in mice carrying a targeted mutation in Nkx6.1. These mutants show a dorsal-to-ventral switch in the identity of progenitors and in the fate of postmitotic neurons. At many axial levels there is a complete block in the generation of V2 interneurons and motor neurons and a compensatory ventral expansion in the domain of generation of V1 neurons, demonstrating the essential functions of Nkx6.1 in regional patterning and neuronal fate determination. |
