| First Author | Azar DT | Year | 2008 |
| Journal | Curr Eye Res | Volume | 33 |
| Issue | 11 | Pages | 954-62 |
| PubMed ID | 19085378 | Mgi Jnum | J:142651 |
| Mgi Id | MGI:3821907 | Doi | 10.1080/02713680802461106 |
| Citation | Azar DT, et al. (2008) Effect of MT1-MMP deficiency and overexpression in corneal keratocytes on vascular endothelial cell migration and proliferation. Curr Eye Res 33(11):954-62 |
| abstractText | PURPOSE: To determine the effect of keratocyte-derived MT1-MMP on calf pulmonary artery endothelial cell (CPAE) proliferation and migration. METHODS: Keratocyte lines were generated from MT1-MMP knockout (KO) and wild type (WT) mice. WT keratocytes were transfected with WT or mutant MT1-MMP DNAs (DeltaTC or E240A). The effect of keratocyte-conditioned media on CPAE proliferation and migration was assayed. RESULTS: KO keratocyte conditioned media resulted in the greatest increase of CPAE cell proliferation (190.5+/-6.0%; p<0.01). WT keratocyte conditioned media showed higher CPAE proliferation (155.4+/-3.6%) than WT/MT1-MMP-transfected keratocytes (119.7+/-2.2%; p<0.001). Migration assays confirmed these findings. CONCLUSIONS: Keratocyte-derived MT1-MMP has anti-angiogenic effects in CPAE cells. |
