| First Author | Kato T | Year | 2001 |
| Journal | FEBS Lett | Volume | 508 |
| Issue | 2 | Pages | 187-90 |
| PubMed ID | 11718713 | Mgi Jnum | J:72813 |
| Mgi Id | MGI:2153634 | Doi | 10.1016/s0014-5793(01)02897-6 |
| Citation | Kato T, et al. (2001) Diminished corneal angiogenesis in gelatinase A-deficient mice. FEBS Lett 508(2):187-90 |
| abstractText | The goal of the present study was to define the role of gelatinase A in angiogenesis. We performed corneal micropocket assays in gelatinase A-deficient mice and their age-matched wild-type littermates. The corneal neovascular area in gelatinase A-deficient mice (0.15+/-0.14 mm(2)) was significantly less than that of wild-type littermates (0.53+/-0.35 mm(2); P<0.01). Similarly, aortic ring assays showed significant reduction of endothelial outgrowth in gelatinase A-deficient mice (0.26+/-0.14 mm(2)) as compared to wild-type littermates (0.44+/-0.06 mm(2); P<0.05). These results suggest that gelatinase A may play an important role in the regulation of corneal angiogenesis. |
