| Primary Identifier | MGI:2386277 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Tyrobp |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exons 3 and 4 were deleted by the insertion of a floxed neo cassette, which was subsequently excised via the in vitro expression of cre recombinase. The targeted region encoded the transmembrane domain and a portion of the cytoplasmic domain including the first tyrosine of the immunoreceptor tyrosine-based activation motif (ITAM). The ablation of protein expression in homozygous mutant mice was confirmed via immunohistochemical analysis of spleen sections. |
