| First Author | Feng X | Year | 2010 |
| Journal | Blood | Volume | 115 |
| Issue | 3 | Pages | 510-8 |
| PubMed ID | 19965654 | Mgi Jnum | J:156832 |
| Mgi Id | MGI:4421479 | Doi | 10.1182/blood-2009-07-232694 |
| Citation | Feng X, et al. (2010) Foxp1 is an essential transcriptional regulator for the generation of quiescent naive T cells during thymocyte development. Blood 115(3):510-8 |
| abstractText | Proper thymocyte development is required to establish T-cell central tolerance and to generate naive T cells, both of which are essential for T-cell homeostasis and a functional immune system. Here we demonstrate that the loss of transcription factor Foxp1 results in the abnormal development of T cells. Instead of generating naive T cells, Foxp1-deficient single-positive thymocytes acquire an activated phenotype prematurely in the thymus and lead to the generation of peripheral CD4(+) T and CD8(+) T cells that exhibit an activated phenotype and increased apoptosis and readily produce cytokines upon T-cell receptor engagement. These results identify Foxp1 as an essential transcriptional regulator for thymocyte development and the generation of quiescent naive T cells. |
