| First Author | Imanishi T | Year | 2020 |
| Journal | Cell Rep | Volume | 32 |
| Issue | 3 | Pages | 107911 |
| PubMed ID | 32698010 | Mgi Jnum | J:313365 |
| Mgi Id | MGI:6705680 | Doi | 10.1016/j.celrep.2020.107911 |
| Citation | Imanishi T, et al. (2020) mTORC1 Signaling Controls TLR2-Mediated T-Cell Activation by Inducing TIRAP Expression. Cell Rep 32(3):107911 |
| abstractText | Effector, but not naive, T cells are activated by toll-like receptor-2 (TLR2) stimulation, leading to cytokine production and proliferation. We found that the differential response is attributable to the lack of expression of the adaptor protein TIRAP in naive T cells. TIRAP expression is induced upon T-cell receptor (TCR) stimulation and sustained by strong interleukin-2 (IL-2) signals. Expression of TIRAP requires TCR- and IL-2-induced mTORC1 activation. TLR2 stimulation induced the activation of nuclear factor kappaB (NF-kappaB) and ERK, leading to much higher production of interferon-gamma (IFN-gamma) by T helper 1 (Th1) cells cultured in a high concentration of IL-2 than by those cultured in a low concentration of IL-2. In contrast, TLR2 stimulation induces mTORC1 activation through TIRAP, which is essential for TLR2-mediated IFN-gamma production. These data demonstrate that the mTORC1 signal confers the response to TLR2 signaling by inducing TIRAP expression and that the TIRAP-mTORC1 axis is critical for TLR2-mediated IFN-gamma production by effector T cells. |
