| First Author | Cobb BS | Year | 2006 |
| Journal | J Exp Med | Volume | 203 |
| Issue | 11 | Pages | 2519-27 |
| PubMed ID | 17060477 | Mgi Jnum | J:124629 |
| Mgi Id | MGI:3722047 | Doi | 10.1084/jem.20061692 |
| Citation | Cobb BS, et al. (2006) A role for Dicer in immune regulation. J Exp Med 203(11):2519-27 |
| abstractText | Micro RNAs (miRNAs) regulate gene expression at the posttranscriptional level. Here we show that regulatory T (T reg) cells have a miRNA profile distinct from conventional CD4 T cells. A partial T reg cell-like miRNA profile is conferred by the enforced expression of Foxp3 and, surprisingly, by the activation of conventional CD4 T cells. Depleting miRNAs by eliminating Dicer, the RNAse III enzyme that generates functional miRNAs, reduces T reg cell numbers and results in immune pathology. Dicer facilitates, in a cell-autonomous fashion, the development of T reg cells in the thymus and the efficient induction of Foxp3 by transforming growth factor beta. These results suggest that T reg cell development involves Dicer-generated RNAs. |
