| First Author | Merana GR | Year | 2022 |
| Journal | Cell Rep | Volume | 39 |
| Issue | 9 | Pages | 110891 |
| PubMed ID | 35649365 | Mgi Jnum | J:326149 |
| Mgi Id | MGI:7294039 | Doi | 10.1016/j.celrep.2022.110891 |
| Citation | Merana GR, et al. (2022) Intestinal inflammation alters the antigen-specific immune response to a skin commensal. Cell Rep 39(9):110891 |
| abstractText | Resident microbes in skin and gut predominantly impact local immune cell function during homeostasis. However, colitis-associated neutrophilic skin disorders suggest possible breakdown of this compartmentalization with disease. Using a model wherein neonatal skin colonization by Staphylococcus epidermidis facilitates generation of commensal-specific tolerance and CD4(+) regulatory T cells (Tregs), we ask whether this response is perturbed by gut inflammation. Chemically induced colitis is accompanied by intestinal expansion of S. epidermidis and reduces gut-draining lymph node (dLN) commensal-specific Tregs. It also results in reduced commensal-specific Tregs in skin and skin-dLNs and increased skin neutrophils. Increased CD4(+) circulation between gut and skin dLN suggests that the altered cutaneous response is initiated in the colon, and resistance to colitis-induced effects in Cd4(cre)Il1r1(fl/fl) mice implicate interleukin (IL)-1 in mediating the altered commensal-specific response. These findings provide mechanistic insight into observed connections between inflammatory skin and intestinal diseases. |
