| First Author | Thauland TJ | Year | 2019 |
| Journal | Front Immunol | Volume | 10 |
| Pages | 2706 | PubMed ID | 31824498 |
| Mgi Jnum | J:355203 | Mgi Id | MGI:7737851 |
| Doi | 10.3389/fimmu.2019.02706 | Citation | Thauland TJ, et al. (2019) The Actin-Capping Protein Alpha-Adducin Is Required for T-Cell Costimulation. Front Immunol 10:2706 |
| abstractText | Alpha-adducin (Add1) is a critical component of the actin-spectrin network in erythrocytes, acting to cap the fast-growing, barbed ends of actin filaments, and recruiting spectrin to these junctions. Add1 is highly expressed in T cells, but its role in T-cell activation has not been examined. Using a conditional knockout model, we show that Add1 is necessary for complete activation of CD4+ T cells in response to low levels of antigen but is dispensable for CD8+ T cell activation and response to infection. Surprisingly, costimulatory signals through CD28 were completely abrogated in the absence of Add1. This study is the first to examine the role of actin-capping in T cells, and it reveals a previously unappreciated role for the actin cytoskeleton in regulating costimulation. |
