| First Author | Kitagawa Y | Year | 2017 |
| Journal | Nat Immunol | Volume | 18 |
| Issue | 2 | Pages | 173-183 |
| PubMed ID | 27992401 | Mgi Jnum | J:259389 |
| Mgi Id | MGI:6143911 | Doi | 10.1038/ni.3646 |
| Citation | Kitagawa Y, et al. (2017) Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment. Nat Immunol 18(2):173-183 |
| abstractText | Most Foxp3(+) regulatory T (Treg) cells develop in the thymus as a functionally mature T cell subpopulation specialized for immune suppression. Their cell fate appears to be determined before Foxp3 expression; yet molecular events that prime Foxp3(-) Treg precursor cells are largely obscure. We found that Treg cell-specific super-enhancers (Treg-SEs), which were associated with Foxp3 and other Treg cell signature genes, began to be activated in Treg precursor cells. T cell-specific deficiency of the genome organizer Satb1 impaired Treg-SE activation and the subsequent expression of Treg signature genes, causing severe autoimmunity due to Treg cell deficiency. These results suggest that Satb1-dependent Treg-SE activation is crucial for Treg cell lineage specification in the thymus and that its perturbation is causative of autoimmune and other immunological diseases. |
