| First Author | Shaw LA | Year | 2016 |
| Journal | Nat Immunol | Volume | 17 |
| Issue | 7 | Pages | 834-43 |
| PubMed ID | 27213691 | Mgi Jnum | J:259464 |
| Mgi Id | MGI:6142836 | Doi | 10.1038/ni.3461 |
| Citation | Shaw LA, et al. (2016) Id2 reinforces TH1 differentiation and inhibits E2A to repress TFH differentiation. Nat Immunol 17(7):834-43 |
| abstractText | The differentiation of helper T cells into effector subsets is critical to host protection. Transcription factors of the E-protein and Id families are important arbiters of T cell development, but their role in the differentiation of the TH1 and TFH subsets of helper T cells is not well understood. Here, TH1 cells showed more robust Id2 expression than that of TFH cells, and depletion of Id2 via RNA-mediated interference increased the frequency of TFH cells. Furthermore, TH1 differentiation was blocked by Id2 deficiency, which led to E-protein-dependent accumulation of effector cells with mixed characteristics during viral infection and severely impaired the generation of TH1 cells following infection with Toxoplasma gondii. The TFH cell-defining transcriptional repressor Bcl6 bound the Id2 locus, which provides a mechanism for the bimodal Id2 expression and reciprocal development of TH1 cells and TFH cells. |
