| First Author | Luda KM | Year | 2016 |
| Journal | Immunity | Volume | 44 |
| Issue | 4 | Pages | 860-74 |
| PubMed ID | 27067057 | Mgi Jnum | J:257991 |
| Mgi Id | MGI:6112166 | Doi | 10.1016/j.immuni.2016.02.008 |
| Citation | Luda KM, et al. (2016) IRF8 Transcription-Factor-Dependent Classical Dendritic Cells Are Essential for Intestinal T Cell Homeostasis. Immunity 44(4):860-74 |
| abstractText | The role of dendritic cells (DCs) in intestinal immune homeostasis remains incompletely defined. Here we show that mice lacking IRF8 transcription-factor-dependent DCs had reduced numbers of T cells in the small intestine (SI), but not large intestine (LI), including an almost complete absence of SI CD8alphabeta(+) and CD4(+)CD8alphaalpha(+) T cells; the latter requiring beta8 integrin expression by migratory IRF8 dependent CD103(+)CD11b(-) DCs. SI homing receptor induction was impaired during T cell priming in mesenteric lymph nodes (MLN), which correlated with a reduction in aldehyde dehydrogenase activity by SI-derived MLN DCs, and inefficient T cell localization to the SI. These mice also lacked intestinal T helper 1 (Th1) cells, and failed to support Th1 cell differentiation in MLN and mount Th1 cell responses to Trichuris muris infection. Collectively these results highlight multiple non-redundant roles for IRF8 dependent DCs in the maintenance of intestinal T cell homeostasis. |
