| First Author | Nish SA | Year | 2014 |
| Journal | Elife | Volume | 3 |
| Pages | e01949 | PubMed ID | 24842874 |
| Mgi Jnum | J:213220 | Mgi Id | MGI:5583911 |
| Doi | 10.7554/eLife.01949 | Citation | Nish SA, et al. (2014) T cell-intrinsic role of IL-6 signaling in primary and memory responses. Elife 3:e01949 |
| abstractText | Innate immune recognition is critical for the induction of adaptive immune responses; however the underlying mechanisms remain incompletely understood. In this study, we demonstrate that T cell-specific deletion of the IL-6 receptor alpha chain (IL-6Ralpha) results in impaired Th1 and Th17 T cell responses in vivo, and a defect in Tfh function. Depletion of Tregs in these mice rescued the Th1 but not the Th17 response. Our data suggest that IL-6 signaling in effector T cells is required to overcome Treg-mediated suppression in vivo. We show that IL-6 cooperates with IL-1beta to block the suppressive effect of Tregs on CD4(+) T cells, at least in part by controlling their responsiveness to IL-2. In addition, although IL-6Ralpha-deficient T cells mount normal primary Th1 responses in the absence of Tregs, they fail to mature into functional memory cells, demonstrating a key role for IL-6 in CD4(+) T cell memory formation.DOI: http://dx.doi.org/10.7554/eLife.01949.001. |
