| First Author | Zhang Y | Year | 2017 |
| Journal | Sci Rep | Volume | 7 |
| Issue | 1 | Pages | 8952 |
| PubMed ID | 28827576 | Mgi Jnum | J:265040 |
| Mgi Id | MGI:6198865 | Doi | 10.1038/s41598-017-08357-4 |
| Citation | Zhang Y, et al. (2017) Arp2/3 complex controls T cell homeostasis by maintaining surface TCR levels via regulating TCR(+) endosome trafficking. Sci Rep 7(1):8952 |
| abstractText | T cell receptor (TCR) signaling is important for T cell homeostasis and function. However, how surface TCR levels are regulated and its biological significance on T cells remains largely unknown. Here, we show that the T cell-specific deletion of Arpc2, a component of Arp2/3 complex, results in compromised peripheral T cell homeostasis. Arp2/3 complex-nucleated actin filaments are essential for maintaining surface TCR levels by regulating TCR(+) endosome trafficking in resting state and controlling polarization of TCR(+) endosomes during immune synapse formation in T cells. Additionally, Arpc2-TKO T cells are unable to form immune synapse. Interestingly, defected T cell homeostasis is caused by reduced surface TCR levels but not impaired immune synapse formation. Collectively, our findings suggest that Arp2/3 complex-nucleated actin filaments are required for maintaining surface TCR levels via regulating TCR(+) endosome trafficking which is essential for T cell homeostasis. |
