| First Author | Slayback DL | Year | 2000 |
| Journal | Bone Marrow Transplant | Volume | 26 |
| Issue | 9 | Pages | 931-8 |
| PubMed ID | 11100271 | Mgi Jnum | J:66655 |
| Mgi Id | MGI:1928805 | Doi | 10.1038/sj.bmt.1702661 |
| Citation | Slayback DL, et al. (2000) Genetic factors influencing the development of chronic graft-versus-host disease in a murine model. Bone Marrow Transplant 26(9):931-8 |
| abstractText | Graft-versus-host disease (GVHD) is a major complication of bone marrow transplantation that can occur in either acute or chronic forms. Much of the long-term pathology seen in chronic GVHD is a result of autoantibody production. In the DBA/2-->B6D2F1 murine model of chronic GVHD, anti-ssDNA autoantibodies can be detected by 14 days post cell transfer. These autoantibodies are not observed in B6D2F1 recipients of cells from C57BL/6 or B10.D2 donors, which develop acute rather than chronic GVHD. Therefore, in this model, donor genetic factors predispose to the development of chronic GVHD in recipients. We performed a genetic analysis aimed at mapping donor loci that influence the magnitude of early autoantibody production in B6D2F1 recipients of cells from DBA/2 donor mice. Linkage analysis suggested an influence of two loci: a locus on chromosome 11 linked to D11Mit278 and a locus on chromosome 4 linked to D4Mit226. The locus on chromosome 11 also appeared to influence the development of renal pathology associated with chronic GVHD. |
