| Primary Identifier | MGI:2386745 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Stat6 |
| Transmission | Germline | Strain of Origin | 129S/SvEv-Gpi1<c> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The first coding exon was replaced with a neomycin resistance gene via homologous recombination. Immunoprecipitation and Western blot analysis using an antibody directed against the C-terminus of the protein did not detect wild-type gene product in homozygous mutant animals. However, a smaller protein was detected at low levels, possibly produced from residual transcripts. Il4-induced DNA-binding activity of Stat6 was not present in homozygous mutant animals. |
