| First Author | Malaviya R | Year | 2002 |
| Journal | J Immunol | Volume | 168 |
| Issue | 1 | Pages | 421-6 |
| PubMed ID | 11751988 | Mgi Jnum | J:126022 |
| Mgi Id | MGI:3760365 | Doi | 10.4049/jimmunol.168.1.421 |
| Citation | Malaviya R, et al. (2002) Role of STAT6 in IgE receptor/FcepsilonRI-mediated late phase allergic responses of mast cells. J Immunol 168(1):421-6 |
| abstractText | In this study we show that IgE receptor engagement triggers activation of STAT6 in mast cells. We sought to determine the role of STAT6 activation in IgE receptor-mediated mast cell responses using STAT6 knockout mice. After IgE receptor engagement, bone marrow mast cells from STAT6(-/-) mice exhibited normal histamine and leukotriene C(4) release, but their cytokine release was markedly reduced. In accordance with these in vitro data, IgE/Ag-challenged STAT6(-/-) mice showed normal early phase, but severely impaired late phase, allergic reactions. These findings provide unprecedented evidence that STAT6 plays a pivotal role in mast cell responses to IgE/Ag stimulation. |
