| First Author | Yukawa K | Year | 2005 |
| Journal | Int J Mol Med | Volume | 16 |
| Issue | 4 | Pages | 673-5 |
| PubMed ID | 16142403 | Mgi Jnum | J:107592 |
| Mgi Id | MGI:3621516 | Citation | Yukawa K, et al. (2005) Reduced prepulse inhibition of startle in STAT6-deficient mice. Int J Mol Med 16(4):673-5 |
| abstractText | To determine the role of STAT6 transcription factors in brain function, we performed a battery of mouse behavioral analyses of STAT6-deficient mice. We recently showed that STAT6-deficient mice displayed increased locomotor activities and had reduced levels of dopamine transporter (DAT) expression in the striatum. To further examine the behavioral effects of STAT6 deficiency, we subjected STAT6-deficient mice to behavior task testing prepulse inhibition (PPI) of the auditory startle response. In acoustic prepulse conditions, STAT6-deficient mice displayed significantly lower levels of PPI in acoustic startle than did wild-type mice, indicating their sensorimotor gating deficits. Thus, STAT6 transcription factors may be crucially implicated in sensorimotor gating by modulating the expression of several genes, including DAT in brain neurons. |
