| First Author | Mackay F | Year | 1999 |
| Journal | J Exp Med | Volume | 190 |
| Issue | 11 | Pages | 1697-710 |
| PubMed ID | 10587360 | Mgi Jnum | J:58798 |
| Mgi Id | MGI:1350447 | Doi | 10.1084/jem.190.11.1697 |
| Citation | Mackay F, et al. (1999) Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations. J Exp Med 190(11):1697-710 |
| abstractText | The cause of many autoimmune and inflammatory diseases is unresolved, although dysregulated production of tumor necrosis factor (TNF) family members appears to be important in many cases. BAFF, a new member of the TNF family, binds to B cells and costimulates their growth in vitro. Mice transgenic for BAFF have vastly increased numbers of mature B and effector T cells, and develop autoimmune-like manifestations such as the presence of high levels of rheumatoid factors, circulating immune complexes, anti-DNA autoantibodies, and immunoglobulin deposition in the kidneys. This phenotype is reminiscent of certain human autoimmune disorders and suggests that dysregulation of BAFF expression may be a critical element in the chain of events leading to autoimmunity. |
