| First Author | Liu X | Year | 2009 |
| Journal | Biochem Biophys Res Commun | Volume | 388 |
| Issue | 1 | Pages | 161-6 |
| PubMed ID | 19653998 | Mgi Jnum | J:152719 |
| Mgi Id | MGI:4359562 | Doi | 10.1016/j.bbrc.2009.07.148 |
| Citation | Liu X, et al. (2009) Oxytocin deficiency impairs maternal skeletal remodeling. Biochem Biophys Res Commun 388(1):161-6 |
| abstractText | We have reported that the posterior pituitary hormone, oxytocin (OT), known for its effects in inducing parturition, lactation and social bonding, is also a skeletal hormone. Here, we demonstrate that OT plays a key role in enabling maternal skeletal mobilization during pregnancy by enhancing the formation of bone resorbing osteoclasts. Osteoclast formation ex vivo is thus diminished in pregnant mothers with genetic OT-deficiency. OT(-/-) pups at day E20 also show a defect in trabecular bone. microCT measurements reveal normal bone volume, but increased trabecular numbers, suggesting that trabeculae in OT(-/-) pups are hypomineralized. We suggest that OT facilitates intergenerational transfer of calcium ions from a pregnant mother to the pups. |
