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Allele : H2-Oa<tm1Dma> histocompatibility 2, O region alpha locus; targeted mutation 1, Daniel M Altmann

Primary Identifier  MGI:2386294 Allele Type  Targeted
Attribute String  Null/knockout, Reporter Gene  H2-Oa
Transmission  Germline Strain of Origin  129/Sv
Is Recombinase  false Is Wild Type  false
molecularNote  Sequence extending from nucleotide position 21 in exon 1 through position 861 in exon 5 was replaced with a cassette containing lacZ and neo via homologous recombination. Transcript was undetected in homozygous mutant mice via RT-PCR analysis of total spleen and thymis RNA. Homozygous mutant mice were shown to lack the endogenous protein via Western blot analysis of splenocytes.
  • mutations:
  • Intragenic deletion,
  • Insertion
  • synonyms:
  • H2-Oa-,
  • H2-Oa-
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

4 Publication categories