| Primary Identifier | MGI:2386788 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Xbp1 |
| Transmission | Germline | Strain of Origin | 129S2/SvPas |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A 0.8 kb genomic region between exons 1 and 2 was replaced with a neomycin resistance cassette via homologous recombination resulting in a shift in the downstream reading frame. Northern blot analysis of homozygous mutant embryos did not detect wild-type transcript, but instead detected a larger mutant transcript which contained the neo insert. Western blot of fetal livers did not detect protein product in homozygous mutants. |
