| First Author | Li G | Year | 2012 |
| Journal | Free Radic Biol Med | Volume | 52 |
| Issue | 2 | Pages | 392-401 |
| PubMed ID | 22100973 | Mgi Jnum | J:179384 |
| Mgi Id | MGI:5302144 | Doi | 10.1016/j.freeradbiomed.2011.10.490 |
| Citation | Li G, et al. (2012) 8-Oxoguanine-DNA glycosylase 1 deficiency modifies allergic airway inflammation by regulating STAT6 and IL-4 in cells and in mice. Free Radic Biol Med 52(2):392-401 |
| abstractText | 8-Oxoguanine-DNA glycosylase (OGG-1) is a base excision DNA repair enzyme; however, its function in modulating allergic diseases remains undefined. Using OGG-1 knockout (KO) mice, we show that this protein affects allergic airway inflammation after sensitization and challenge by ovalbumin(OVA). OGG-1 KO mice exhibited less inflammatory cell infiltration and reduced oxidative stress in the lungs after OVA challenge compared to WT mice. The KO phenotype included decreased IL-4, IL-6, IL-10, and IL-17 in lung tissues. In addition, OGG-1 KO mice showed decreased expression and phosphorylation of STAT6 as well as NF-kappaB. Down-regulation of OGG-1 by siRNA lowered ROS and IL-4 levels but increased IFN-gamma production in cultured epithelial cells after exposure to house dust mite extracts. OGG-1 may affect the levels of oxidative stress and proinflammatory cytokines during asthmatic conditions. OGG-1 deficiency negatively regulates allergen-induced airway inflammatory response. |
