First Author | Deonarain R | Year | 2000 |
Journal | J Virol | Volume | 74 |
Issue | 7 | Pages | 3404-9 |
PubMed ID | 10708458 | Mgi Jnum | J:61048 |
Mgi Id | MGI:1354270 | Doi | 10.1128/jvi.74.7.3404-3409.2000 |
Citation | Deonarain R, et al. (2000) Impaired antiviral response and alpha/beta interferon induction in mice lacking beta interferon. J Virol 74(7):3404-9 |
abstractText | We have generated mice lacking the gene for beta interferon and report that they are highly susceptible to vaccinia virus infection. Furthermore, in cultured embryo fibroblasts, viral induction of alpha interferon and of 2-5A synthetase genes is impaired. We also show that beta interferon does not prime its own expression. |