| First Author | Shibata R | Year | 2008 |
| Journal | FEBS Lett | Volume | 582 |
| Issue | 11 | Pages | 1607-12 |
| PubMed ID | 18423403 | Mgi Jnum | J:136274 |
| Mgi Id | MGI:3795817 | Doi | 10.1016/j.febslet.2008.04.006 |
| Citation | Shibata R, et al. (2008) Adiponectin promotes endothelial progenitor cell number and function. FEBS Lett 582(11):1607-12 |
| abstractText | Obesity-linked diseases are associated with suppressed endothelial progenitor cell (EPC) function. Adiponectin is an adipose-derived protein that is downregulated in obese and diabetic subjects. Here, we investigated the effects of adiponectin on EPCs. EPC levels did not increase in adiponectin deficient (APN-KO) in response to hindlimb ischemia. Adenovirus-mediated delivery of adiponectin increased EPC levels in both WT and APN-KO mice. Incubation of human peripheral blood mononuclear cells with adiponectin led to an increase of the number of EPCs. Adiponectin induced EPC differentiation into network structures and served as a chemoattractant in EPC migration assays. These data suggest that hypoadiponectinemia may contribute to the depression of EPC levels that are observed in patients with obesity-related cardiovascular disorders. |
