| First Author | Quoix N | Year | 2007 |
| Journal | FEBS Lett | Volume | 581 |
| Issue | 22 | Pages | 4235-40 |
| PubMed ID | 17706201 | Mgi Jnum | J:165768 |
| Mgi Id | MGI:4838398 | Doi | 10.1016/j.febslet.2007.07.068 |
| Citation | Quoix N, et al. (2007) The GluCre-ROSA26EYFP mouse: a new model for easy identification of living pancreatic alpha-cells. FEBS Lett 581(22):4235-40 |
| abstractText | The control of glucagon secretion by pancreatic alpha-cells is poorly understood, largely because of the difficulty to recognize living alpha-cells. We describe a new mouse model, referred to as GluCre-ROSA26EYFP (or GYY), allowing easy alpha-cell identification because of specific expression of EYFP. GYY mice displayed normal glycemic control during a fasting/refeeding test or intraperitoneal insulin injection. Glucagon secretion by isolated islets was normally inhibited by glucose and stimulated by adrenaline. [Ca(2+)](c) responses to arginine, adrenaline, diazoxide and tolbutamide, were similar in GYY and control mice. Hence, this new mouse model is a reliable and powerful tool to specifically study alpha-cells. |
