| First Author | Castigli E | Year | 2005 |
| Journal | J Exp Med | Volume | 201 |
| Issue | 1 | Pages | 35-9 |
| PubMed ID | 15630136 | Mgi Jnum | J:95288 |
| Mgi Id | MGI:3525786 | Doi | 10.1084/jem.20032000 |
| Citation | Castigli E, et al. (2005) TACI and BAFF-R mediate isotype switching in B cells. J Exp Med 201(1):35-9 |
| abstractText | The tumor necrosis factor family members BAFF and APRIL induce Ig isotype switching in human B cells. We analyzed the ability of BAFF and APRIL to induce isotype switching in murine B cells to IgG1, IgA, and IgE. APRIL and BAFF each engage two receptors, transmembrane activator and calcium-modulator and cytophilin ligand interactor (TACI) and B cell maturation antigen (BCMA), on B cells. In addition, BAFF engages a third receptor on B cells, BAFF-R. To determine the role of these receptors in isotype switching, we examined B cells from mice deficient in TACI, BCMA, and BAFF-R. The results obtained indicate that both TACI and BAFF-R are able to transduce signals that result in isotype switching. |
