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Allele : Shh<tm3Amc> sonic hedgehog; targeted mutation 3, Andrew P McMahon
Primary Identifier  MGI:2387802 Allele Type  Targeted
Attribute String  Null/knockout Gene  Shh
Transmission  Germline Strain of Origin  (129X1/SvJ x 129S1/Sv)F1-Kitl<+>
Is Recombinase  false Is Wild Type  false
molecularNote  A construct containing a nonsense mutation at cysteine codon 199 was inserted at the endogenous locus via homologous recombination. Termination of translation after glycine 198 putatively precludes autoproteolytic activity and the associated process in which a cholesterol, involved in cell surface tethering, is attached to glycine 198.
  • mutations:
  • Insertion,
  • Single point mutation
  • synonyms:
  • Shh<n>,
  • N-Shh,
  • N-Shh,
  • Shh<n>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

4 Publication categories





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