| First Author | Malhotra S | Year | 2009 |
| Journal | J Biol Chem | Volume | 284 |
| Issue | 36 | Pages | 24088-97 |
| PubMed ID | 19586920 | Mgi Jnum | J:154884 |
| Mgi Id | MGI:4410417 | Doi | 10.1074/jbc.M109.014209 |
| Citation | Malhotra S, et al. (2009) B cell antigen receptor endocytosis and antigen presentation to T cells require Vav and dynamin. J Biol Chem 284(36):24088-97 |
| abstractText | Antigen binding to the B cell antigen receptor (BCR) initiates an array of signaling events. These include endocytosis of ligand-receptor complexes via clathrin-coated pits, trafficking of the internalized ligand to lysosomes, degradation of the associated proteins to peptides, and peptide presentation on nascent major histocompatibility complex class II to T cells. The signal transduction events supporting BCR internalization are not well understood. We have identified a pathway supporting BCR internalization that includes the Vav1 and/or Vav3 isoforms and the GTPase dynamin. Vav1 and -3 are not required for B cell development and maturation, nor for a variety of BCR-induced signaling events nor for BCR signaling leading to major histocompatibility complex class II and CD80 expression, but Vav1 and/or -3 are absolutely required for BCR endocytosis and BCR-induced Rac-GTP loading. This is the first demonstration of a link between Vav and Rac in BCR internalization leading to antigen presentation to T cells. |
