| First Author | Swat W | Year | 2003 |
| Journal | Int Immunol | Volume | 15 |
| Issue | 2 | Pages | 215-21 |
| PubMed ID | 12578851 | Mgi Jnum | J:110987 |
| Mgi Id | MGI:3652480 | Doi | 10.1093/intimm/dxg021 |
| Citation | Swat W, et al. (2003) Essential role for Vav1 in activation, but not development, of gammadelta T cells. Int Immunol 15(2):215-21 |
| abstractText | Vav1 is a guanine nucleotide exchange factor essential in the development and function of alphabeta lineage T cells. Here we report that in contrast to profound effects on pre-TCR- or alphabeta TCR-dependent events in thymocyte development, Vav1 deficiency has no detectable effect on the development of gammadelta T cells. Strikingly, however, these gammadelta T cells are markedly deficient in signaling through the gammadelta TCR, as evidenced by a lack of proliferation and cytokine production in response to stimulation with anti-gammadelta TCR antibodies. We propose that Vav1 has a unique and non-redundant role in the initiation of signaling downstream of the gammadelta TCR in lymphocytes. |
