Primary Identifier | MGI:2386993 | Allele Type | Targeted |
Attribute String | Humanized sequence | Gene | Il6st |
Transmission | Germline | Strain of Origin | Not Specified |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A human Il6st cDNA fragment carrying tyrosine to phenylalanine substitutions at amino acids 767, 814, 905, and 915, was used to replaced the corresponding region of the mouse gene. A downstream neomycin resistance cassette was also inserted for positive selection. |