| First Author | Gorelik L | Year | 2004 |
| Journal | J Immunol | Volume | 172 |
| Issue | 2 | Pages | 762-6 |
| PubMed ID | 14707045 | Mgi Jnum | J:87645 |
| Mgi Id | MGI:3027371 | Doi | 10.4049/jimmunol.172.2.762 |
| Citation | Gorelik L, et al. (2004) Cutting Edge: BAFF regulates CD21/35 and CD23 expression independent of its B cell survival function. J Immunol 172(2):762-6 |
| abstractText | Herein we demonstrate that B cell-activating factor of the TNF family (BAFF), a B cell survival factor, also regulates CD21/35 and CD23 expression. BAFF blockade in wild-type mice down-modulates CD21/35 and CD23 on B cells while survival remains intact, and BAFF exposure causes elevated CD21/35 and CD23 expression. Similar down-modulation is observed in bcl-2-transgenic mice treated with a BAFF inhibitor. This is the first evidence that BAFF has a function independent of B cell survival. Reports using CD21/35 and CD23 expression to assess splenic B cell subsets in BAFF-null mice concluded a lack of B cells beyond the immature stage. Since CD21/35 and CD23 are inadequate for delineating B cell subpopulations in BAFF-null mice, we used expression of BAFF-R and several B cell markers to identify more mature splenic B cells in these mice. These data broaden our understanding of BAFF function and correct the view that BAFF-null mice lack mature B cells. |
