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Allele : Igh-7<tm1Led> immunoglobulin heavy chain 7 (heavy chain of IgE); targeted mutation 1, Philip Leder

Primary Identifier  MGI:2387579 Allele Type  Targeted
Attribute String  Null/knockout Gene  Igh-7
Transmission  Germline Strain of Origin  129S4/SvJae
Is Recombinase  false Is Wild Type  false
molecularNote  Exons 1 through 4 were replaced by a neomycin selection cassette inserted via homologous recombination. Transcript was undetected by Northern blot analysis of splenocytes obtained from homozygous mutant mice and stimulated with interleukin-4 and LPS. ELISA confirmed the absence of IgE.
  • mutations:
  • Intragenic deletion,
  • Insertion
  • synonyms:
  • IgE<->,
  • IgE<->
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

2 Carried By

0 Driven By

32 Publication categories