| Primary Identifier | MGI:2387580 | Allele Type | Targeted |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Thra |
| Transmission | Germline | Strain of Origin | 129S6/SvEvTac |
| Is Recombinase | false | Is Wild Type | false |
| description | Phenotypic Similarity to Human Syndrome: Thyroxine-Resistant Skeletal Dysplasia J:217018. This is a newly identified genetic disorder that has not been officially named. |
| molecularNote | A targeting construct was engineered to incorporate a mutation of Thrb into the endogenous locus. The construct contained a frameshift mutation followed by a portion of human THRB obtained from a patient with resistance to thyroid hormone (RTH). Expression of the mutant allele was confirmed by Northern blot analysis. |
